Title: Glyphosate exposure exacerbates neuroinflammation and Alzheimer’s disease
Abstract: Glyphosate use has increased alarmingly yet little is known about its effects on the brain. This study found that mice dosed with glyphosate for 14 days showed glyphosate and its major metabolite aminomethylphosphonic acid present in brain tissue of the mice, with corresponding increases in pro-inflammatory factor TNF-⍺ which is elevated in neurodegenerative disorders such as Alzheimer’s Disease (AD). The study investigated whether glyphosate exposure serves as an accelerant of AD pathogenesis. Additionally, the study examined whether glyphosate and aminomethylphosphonic acid remain in the brain after a recovery period. It was found that aminomethylphosphonic acid was detectable in the brains of glyphosate-dosed mice despite the 6-month recovery. Glyphosate-dosed mice showed reduced survival, increased thigmotaxia (a behavioral response to tactile stimuli). Notably, we found increased pro- and anti-inflammatory cytokines and chemokines ()persisting in brain tissue and peripheral blood plasma. Taken together, the results are the first to demonstrate that despite an extended recovery period, exposure to glyphosate elicits long-lasting pathological consequences. As glyphosate use continues to rise, more research is needed to elucidate the impact of this herbicide and its metabolites on the human brain and their potential contribution to dysfunctions observed in neureogenerative diseases.
